IB DP Biology- D2.2 Gene expression-IB Style Questions For HL Paper 1A -New Syllabus
Question
Researchers studying twins measured methylation levels of amino acids associated with chromosome 2. Twin 1 showed significantly and consistently higher methylation than twin 2. Which explanation best accounts for this observation?
B. Removal of the histone from the chromosome in twin 2
C. The DNA base sequence of twin 1 was altered
D. Cytosines in promoters of twin 2 are more methylated than in twin 1
▶️ Answer/Explanation
✅ Answer: (A)
Question
What is a consequence of nucleases binding to mRNA?
(B) mRNA binds to ribosomes.
(C) More mRNA is synthesized.
(D) mRNA cannot be translated again.
▶️ Answer/Explanation
Correct Answer: \( \boxed{\mathbf{D}} \)
Nucleases degrade mRNA molecules. Once an mRNA molecule is broken down, it can no longer bind to ribosomes for translation, so it cannot be translated again into a protein.
Question
What is consistently located at the same loci on homologous chromosomes?
A. Alleles with the same function
B. Alleles with identical base sequences
C. Genes with identical base pairs
D. Genes with the same mutations
▶️Answer/Explanation
Answer: A. Alleles with the same function
Explanation:

- Homologous chromosomes have genes at the same loci but may carry different alleles of those genes.
- These alleles may have different base sequences but usually code for proteins with the same function (even if one allele is mutated).
- So, while alleles can differ, they generally perform the same biological function at the same loci on homologous chromosomes.
Why other options are incorrect:
B. Alleles with identical base sequences: Alleles can have slight sequence variations.
C. Genes with identical base pairs: Alleles can differ in base pairs due to mutations.
D. Genes with the same mutations: Not all homologous chromosomes carry the same mutation.
