IB DP Biology Option A: Neurobiology and behaviour (Core topics) : A.1 Neural development SL Paper 3

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Question

The diagrams illustrate changes in synapse density of the cerebral cortex from newborn to adult.

[Source: THE POSTNATAL DEVELOPMENT OF THE HUMAN CEREBRAL CORTEX, VOLUMES IVIII, by Jesse LeRoy Conel, Cambridge, Mass.: Harvard University Press, Copyright © 1939, 1941, 1947, 1951, 1955, 1959, 1963, 1967
by the President and Fellows of Harvard College. Copyright © renewed 1967, 1969, 1975, 1979, 1983, 1987, 1991.]

Explain the processes illustrated by the diagrams.

Answer/Explanation

Markscheme

a. at birth neurons are mainly unconnected

b. after birth «up to 2 years» neurons start to make synapses/connections with other neurons

    OR

    up to 2 years the number of synapses/connections increases

c. «increase in synapses» occurs rapidly due to learning/new experiences

d. each neuron can make multiple synapses

e. brain makes many more connections than are required

f. «after 2 years/in adults» neural pruning causes the loss of unused neurons/synapses/connections

Do not accept more neurons are made

[Max 4 Marks]

Question

The images show the early stages and completed outcome of the process of neurulation.

Label the parts I and II on the images.

[2]
a.

Structure Y will eventually elongate to form two structures. State the names of these two structures.

1.

2.

[2]
b.

State the condition that arises if the closure of structure X is incomplete during embryonic development.

[1]
c.
Answer/Explanation

Markscheme

I: neural groove/plate/fold 

II: ectoderm

a.

brain 

spinal cord

b.

spina bifida

c.

Question

The photomicrographs below show time lapse images of a migrating neuron in the grey matter of the cerebrum of an embryo. The time lapse images were taken at one hour intervals. The cell body is the rounded bright area towards the rear of the migrating neuron.

Calculate the rate of movement of the neuron cell body between 0 and 5 h. Working should be shown, giving the units.

[2]
a.

Suggest a reason for the migration of neurons in the embryonic nervous system.

[1]
b.

Outline neural pruning.

[2]
c.
Answer/Explanation

Markscheme

a. cell moves 25−28mm
OR
71−93μm 

b. speed range is 71−93 μm in 5 hours 

c. answer in the range 14−19 μm/h or μm h−1

a.

a. «neural migration» positions cell types from different origins into specific locations 

b. «neural migration» allows formation of connections/synapses 

c. allows for differentiation of cell types/types of neuron

b.

a. neural pruning is the removal of synapses/dendrites/ neural connections 

b. caused by lack of use 

c. it occurs during brain development/between birth and end of puberty 

d. allows new neural connections/makes nervous system more efficient /plasticity 

c.

Question

The diagram shows the early development of the nervous system in embryonic chordates.

Outline the process taking place in the diagram.

[2]
a.

State what occurs to structure X immediately following its formation.

[1]
b.

Outline how spina bifida could occur during embryonic development.

[1]
c.
Answer/Explanation

Markscheme

a. infolding of the ectoderm /neural plate

“Ectoderm” is essential for the mark.

b. formation of the neural tube
OR
neurulation

“Neural tube” or “neurulation” is essential for the mark.

a.

elongation / forms a tube

b.

a. neural tube/structure X does not close properly

b. folic acid/folacin/folate/vitamin B9 deficiency

c. may be due to mutation / genetic condition

c.

Question

The diagram shows an advanced stage during neurulation in humans or chicks.

Label structures I and II

[2]
a.

State the process by which neurons are initially produced in the embryo.

[1]
b.

Outline the plasticity of the nervous system.

[2]
c.
Answer/Explanation

Markscheme

I: neural tube

II: notochord

a.

Differentiation/neurogenesis «in the neural tube»

b.

Plasticity allows the nervous system to adapt «structurally»
OR
plasticity allows cortical remapping/new connections

Neurons «axons» grow in response to stimulation/experience

Unused neurons die/are lost through pruning

Accept synapses in place of neurons

c.
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