Home / A level Biology 2.1 Testing for biological molecules – Exam style question – Paper 2

A level Biology 2.1 Testing for biological molecules – Exam style question – Paper 2

Question

Stem cells are found throughout the human body. Lgr5+ stem cells are found in the lining of the small intestine.

Fig. 2.1 is a flow chart showing stages in the development of one of the daughter cells produced by the mitotic division of an Lgr5+ stem cell.

(a) (i) Explain why stem cells are required in places such as the lining of the small intestine.

(ii) Name the stage of mitosis shown in cell X in Fig. 2.1.

(iii) State the part of the cell cycle shown at Y in Fig. 2.1.

(b) Explain the role of centromeres in the cell cycle.

(c) Fig. 2.2 shows three types of specialised cell that develop from Lgr5+ stem cells in the small intestine.

The structural features of a cell indicate its likely function.

Suggest a function of each of the cells shown in Fig. 2.2, and explain how the structure of each cell supports your suggestion.

▶️ Answer/Explanation
Solution

(a)(i) Stem cells are required in the lining of the small intestine because:

  • They continuously replace old, worn-out, or dead cells that are damaged by food movement and digestive processes.
  • They maintain the pool of stem cells through self-renewal while also producing differentiated cells through division.
  • The intestinal lining has a high turnover rate, requiring constant cell replacement to maintain its function.
  • They ensure genetically identical cells are produced to maintain consistent tissue function.

(a)(ii) Anaphase.

Explanation: This is the stage where sister chromatids separate and move to opposite poles of the cell.

(a)(iii) Cytokinesis.

Explanation: This is the final stage of the cell cycle where the cytoplasm divides to form two separate daughter cells.

(b) The role of centromeres in the cell cycle:

  • They hold sister chromatids together after DNA replication during S phase.
  • They serve as attachment points for spindle fibers during mitosis, allowing proper chromosome alignment and separation.
  • They divide during anaphase, enabling the separation of sister chromatids into daughter chromosomes.
  • This ensures accurate distribution of genetic material to daughter cells.

(c) Specialized cell functions and structural adaptations:

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