IB DP Biology- D1.2 Protein synthesis - IB Style Questions For SL Paper 1A -FA 2025
Question
What occurs during translation?
II. RNA polymerase catalyses polypeptide synthesis
III. Complementary base pairing between codons and anticodons
(A) I and II only
(B) I and III only
(C) II and III only
(D) I, II and III
▶️ Answer/Explanation
✅ Answer: (B)
Question
Which types of interactions are found in a part of a protein with secondary but not tertiary structure?
I. Hydrogen bonds
II. Disulphide bridges
III. Ionic bonds
A. I only
B. I and II only
C. II and III only
D. I, II and III
▶️ Answer/Explanation
Answer: A. I only
Explanation:
A protein’s secondary structure includes regular folding patterns such as alpha-helices and beta-pleated sheets. These are stabilized only by hydrogen bonds formed between the backbone atoms (carbonyl and amide groups) of the polypeptide chain, not by side-chain interactions.
- Disulphide bridges (covalent bonds between cysteine side chains) and ionic bonds (between charged side chains) occur in the tertiary structure — these involve the R-groups and determine the overall 3D conformation of the protein.
- Thus, only hydrogen bonds are characteristic of the secondary structure, while disulphide and ionic interactions are features of the tertiary level of folding.
Answer Evaluation:
I. Correct – Hydrogen bonds occur between backbone atoms in alpha-helices and beta-sheets.
II. Incorrect – Disulphide bridges form between cysteine side chains during tertiary folding.
III. Incorrect – Ionic bonds are interactions between charged side chains and are also part of tertiary structure.
Question
The anticodons of three tRNAs and the amino acids they carry are shown in the table.
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Which base sequence of an mRNA molecule would code for an arginine–leucine–valine tripeptide?
A. GCA AAU CAG
B. GCA AAT CAG
C. CGT TTA GTC
D. CGU UUA GUC
▶️ Answer/Explanation
Answer: D. CGU UUA GUC
Explanation:
Step 1: Understand codon–anticodon pairing
- Codons (on mRNA) are complementary and antiparallel to anticodons (on tRNA).
- If the anticodon is GCA, the codon is CGU (base pairing: G ≡ C, C ≡ G, A ≡ U).
- So we reverse and complement each anticodon:
| tRNA Anticodon | mRNA Codon | Amino Acid |
|---|---|---|
| GCA | CGU | Arginine |
| AAU | UUA | Leucine |
| CAG | GUC | Valine |
Step 2: Assemble the mRNA for Arginine–Leucine–Valine
- Arginine codon: CGU
- Leucine codon: UUA
- Valine codon: GUC
Therefore: CGU UUA GUC → Option D.
Why the others are incorrect:
A. GCA AAU CAG — these are anticodons, not mRNA codons.
B. GCA AAT CAG — contains the letter T, which occurs in DNA, not RNA.
C. CGT TTA GTC — also contains T, so this is a DNA sequence, not mRNA.
