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IB DP Biology SL- Data-Based Questions- IB Style Questions For Paper 1B -FA 2025

Question

A study was conducted to look at the short-term effects of a change in diet on the risk of disease in young adults. The table shows data on the habitual diet of the participants as well as the study diet followed for two weeks.
(a) Comment on the total energy content of the two diets.     [1]
(b) Distinguish between the two diets.  [2]
Total blood plasma cholesterol levels were measured before the study began and once a week after starting the study diet. Mean results are shown in the bar chart, including the standard deviation.
(c) Calculate, showing your working, the percentage change in mean cholesterol level after one week on the study diet.   [2]
(d) (i) Compare the data for plasma insulin levels before and after the study diet. [2]
(ii) State which cells secrete insulin. [1]
(iii) Outline the reason for plasma insulin levels changing in the first 30 minutes of the test. [1]

▶️ Answer/Explanation

(a)
• The mean total energy of the study diet is slightly lower than that of the habitual diet.
• However, the standard deviations overlap, so there is no clear difference in total energy content between the two diets.

(b)
• The diets differ in the proportions of saturated and unsaturated fats, not in total fat.
• The study diet contains a higher percentage of saturated fats and a lower percentage in the habitual diet.
• (Mono- and poly-)unsaturated fats are reduced in the study diet compared with the habitual diet (polyunsaturated fats in the study diet are roughly half those in the habitual diet).
• The study diet has slightly less carbohydrate than the habitual diet.

(c)
Initial mean cholesterol level = \(150\ \text{mg dL}^{-1}\)
Mean cholesterol after 1 week on the study diet = \(165\ \text{mg dL}^{-1}\)

\[ \text{Percentage change} = \frac{\text{new value} – \text{old value}}{\text{old value}} \times 100 = \frac{165 – 150}{150} \times 100 = \frac{15}{150} \times 100 = 10\% \]
✅ Percentage change in mean cholesterol level after one week = 10% increase.

(d) (i)
• Before and after the study diet, plasma insulin levels show the same general pattern: a rapid rise, then a leveling and gradual decrease.
• Both sets of values are very similar at each time point, with overlapping error bars, indicating no significant difference in insulin levels before and after the study diet.
• In both cases, insulin rises for about the first 30–45 minutes after glucose intake.

(d) (ii)
• Insulin is secreted by the β (beta) cells of the islets of Langerhans in the pancreas.

(d) (iii)
• After glucose is consumed, blood glucose concentration rises.
• This stimulates the pancreatic β cells to secrete more insulin to reduce blood glucose levels by increasing glucose uptake into cells.

Markscheme (summary):

(a)
a. Energy is not effectively changed between the two diets;
b. Study diet slightly lower in energy than habitual diet (but means/SD overlap);
c. Habitual diet shows slightly greater variation / higher SD.

(b)
a. They differ in percent of saturated vs unsaturated fats, not total fat;
b. Percent of saturated fats higher in study diet / lower in habitual diet;
c. (Mono/poly)unsaturated fats decreased in study diet compared to habitual diet;
d. Slightly less carbohydrate in the study diet.

(c)
a. \(((165 – 150) \div 150) \times 100\);
b. = 10%;

(d)(i)
a. Both show same pattern of rise, level, then decrease;
b. Both show similar insulin levels at all times (overlapping error bars);
c. Both rise for about 30–45 minutes.

(d)(ii)
a. β cells of pancreas / islets of Langerhans.

(d)(iii)
a. As blood glucose rises, insulin secretion increases to reduce the blood glucose level.

Question

Ebola virus disease (EVD) is the disease in humans and other primates that is caused by the Ebola virus. Fruit bats are the reservoir for the virus and are able to spread the disease without being affected. Humans can become infected by contact with fruit bats or with people infected by the virus, their body fluids or equipment used to treat them.
The table shows data for four African countries that were affected by the 2014–2015 Ebola outbreak.
(a) Identify the country with:
    (i) the largest number of Ebola cases. [1]
    (ii) the largest number of deaths. [1]
(b) Analysis of the data suggests that the number of deaths from EVD is not related to the total population size. State one piece of evidence from the data that would support this analysis. [1]
(c) Based on the mode of transmission of the Ebola virus, suggest a possible reason for the relationship between population density and the number of Ebola cases in these four countries. [1]
The graphs show the progress of the EVD epidemic in Guinea and Liberia for the period April 2014 to May 2015.
[Source: Ebola Situation Report 2 March 2016 and data from International Journal of Infectious Diseases, 38, Ligui Wang et al., Epidemiological features and trends of Ebola virus disease in West Africa, 52–53., Copyright 2015, with permission from Elsevier]
(d) Based on the data, compare and contrast the progress of the epidemic in Liberia and Guinea. [3]
(e) Suggest two possible reasons for the drop in the daily numbers of newly infected cases after October 2014 in Liberia. [2]
An antiviral drug, T-705, was tested in order to establish whether it has potential to treat EVD. The graph shows the data from an in vitro trial of T-705 on cells that had been infected with Ebola virus five days previously. Virus concentration and live cells are shown as percentage of the control.
(f) Based on these data, outline the evidence that T-705 has potential to be used as a treatment for EVD. [2]
(g) District administrators combatting the 2014 Ebola epidemic in West Africa were assisted by international organizations such as the World Health Organization, who provided data on the progress of the epidemic. Suggest one other way in which international organizations can assist with combatting an epidemic of Ebola. [1]

▶️ Answer/Explanation

(a)
(i) Country with the largest number of Ebola cases: Sierra Leone.
(ii) Country with the largest number of deaths: Liberia.

(b)
Evidence that the number of deaths is not related to total population size:
Liberia has the smallest population among the four countries but the highest number of deaths.
Mali has a relatively large population, yet very few deaths from Ebola.
Any one of these contrasting examples shows there is no simple link between population size and deaths.

(c)
• Ebola spreads through close contact with infected individuals, their body fluids or contaminated equipment.
• In countries with higher population density, people are more likely to be in frequent, close contact with each other and with infected individuals, so more opportunities exist for the virus to be transmitted.

(d) Compare and contrast the progress of the epidemic in Liberia and Guinea:
• In both countries, the overall pattern is similar: the number of new cases rises to a peak and then falls again.
• The epidemic in Guinea starts earlier (around April 2014), while in Liberia it starts later (around June 2014).
Liberia reaches its peak number of new cases earlier (around September 2014), whereas Guinea peaks later (around December 2014).
• After the peak, Liberia shows a sharp drop in new cases after October 2014, while Guinea shows more fluctuating numbers and a slower decline.
• The epidemic lasts longer in Guinea (cases continue until at least May 2015), whereas in Liberia the last cases are recorded by about February 2015.
• In general, the number of new cases is higher in Liberia than in Guinea throughout much of the epidemic.

(e) Two possible reasons for the drop in daily numbers of newly infected cases after October 2014 in Liberia:
Improved control measures: quarantine, isolation of infected individuals, better contact tracing, safer burial practices, and stricter infection control in hospitals.
Better medical support and public awareness: more trained healthcare workers, improved hygiene and use of protective equipment, health education campaigns teaching people how to avoid contact with infected body fluids.
Other acceptable ideas include international aid arriving, changes in people’s behaviour (avoiding gatherings), or vaccination programmes (if used), etc.

(f) Evidence that T-705 has potential as a treatment:
• As the concentration of T-705 increases, the virus concentration falls markedly, showing the drug is effective at reducing or inhibiting viral replication.
• The percentage of live cells remains high even at high T-705 concentrations, indicating that the drug is not highly toxic to the host cells in vitro.
Together, these results suggest T-705 can reduce Ebola virus levels without killing many host cells, so it has potential as a treatment for EVD.

(g)
One way international organizations can assist (any one):
• Provide healthcare workers, training and expertise to support local staff.
• Supply personal protective equipment, disinfectants and medical equipment.
• Fund and organize vaccination campaigns or clinical trials.
• Support logistics for quarantine, contact tracing and distribution of supplies.
• Provide financial aid and coordination for emergency response.
Any one clearly described method gains the mark.

Markscheme (key points):

(a)(i) Sierra Leone
(a)(ii) Liberia

(b)
• Country with biggest population (e.g. Mali) has very few deaths;
• Country with smallest population (Liberia) has the greatest number of deaths.

(c)
• Greater population density → more frequent contact with infected people/animals → more transmission.

(d) (examples of valid points)
a. Overall pattern similar in both (rise then fall).
b. Both countries increase during 2014; neither shows an increase in 2015.
c. Sudden drop occurs earlier (Oct–Nov 2014) in Liberia than in Guinea (Dec 2014–Jan 2015).
d. Guinea shows fluctuations; Liberia rises to a peak then falls more smoothly.
e. Epidemic starts earlier (April 2014) in Guinea than in Liberia (June 2014).
f. Epidemic peaks earlier in Liberia (Sept 2014) than in Guinea (Dec 2014).
g. Epidemic lasts longer in Guinea (cases to at least May 2015) than in Liberia (last cases Feb 2015).
h. Numbers of cases generally lower in Guinea than in Liberia.

(e) (any two)
a. Improved medical care/support/supplies/equipment/training of staff/hygiene;
b. Improved public understanding/education/awareness of how to avoid infection;
c. Effect of control measures: quarantine, isolation, travel restrictions;
d. International aid arriving; vaccine use; seasonal or behavioural changes, etc.

(f)
a. Few cells killed, even at high drug concentration;
b. Virus concentration much reduced at 100 μM and especially 1000 μM;
c. Virus concentration decreases as T-705 concentration increases;
d. Therefore, T-705 has high potential as a treatment at adequate dose.

(g)
• Raise awareness/provide information; supply health workers/equipment; train local staff; provide financial support; provide vaccines; issue travel alerts, etc.

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