Question
Ebola virus disease (EVD) is the disease in humans and other primates caused by Ebola virus. Fruit bats are the reservoir for the virus. The table shows data for four African countries affected by the 2014-2015 Ebola outbreak.

a. Identify the country with:
i. the largest number of Ebola cases
ii. the largest number of deaths
b. State one piece of evidence that deaths from EVD are not related to total population size.
c. Suggest a reason for the relationship between population density and number of Ebola cases.
The graphs show the progress of the EVD epidemic in Guinea and Liberia (April 2014-May 2015):

[Source: Ebola Situation Report 2 March 2016 and data from International Journal of Infectious Diseases]
d. Compare and contrast the epidemic progress in Liberia and Guinea.
e. Suggest two reasons for the drop in new cases after October 2014 in Liberia.
Graph showing in vitro trial results of antiviral drug T-705:

f. Outline evidence that T-705 has potential as an EVD treatment.
g. Suggest one way international organizations can assist in combating Ebola epidemics.
▶️ Answer/Explanation
a.
i. Largest number of Ebola cases: Sierra Leone
ii. Largest number of deaths: Liberia
b.
- Mali has the largest population but the fewest deaths
- Liberia has a smaller population but the highest death count
c.
Higher population density increases person-to-person contact, allowing the virus to spread more easily
d.
- Both show an increase and then a decrease in cases
- Liberia’s peak occurred earlier (September 2014); Guinea peaked later
- Liberia had more daily cases at its peak
Guinea’s cases showed more fluctuation month to month
e.
- Government and health authorities introduced control measures like isolation and quarantine
- Public education campaigns reduced risky behaviors
- Better healthcare support and international aid
f.
- As T-705 concentration increased, virus levels dropped sharply
- Live cells remained largely unaffected, suggesting selective toxicity to the virus
g.
- Send medical personnel and equipment
- Provide funding for treatment and prevention
- Support public health campaigns and training for local staff
Markscheme
a.
i. Sierra Leone
ii. Liberia
b. Mali (largest population) had fewest deaths OR Liberia (smallest population) had most deaths
c. Higher density → more frequent contact with infected individuals/animals
d.
• Both show rise then fall, but Liberia peaked earlier (Sep 2014 vs Dec 2014)
• Liberia had higher case numbers overall
• Guinea’s cases fluctuated more than Liberia’s steady rise/fall
e.
• Implementation of control measures (quarantine, hygiene)
• Improved medical care/supplies
• Public education about transmission
f.
• Virus concentration decreases as T-705 concentration increases
• At 1000μM, nearly all viruses were killed with minimal cell death
g. Provide medical supplies/training/funding/public education campaigns
