Home / iGCSE Biology (0610)-10.1 Diseases and immunity – iGCSE Style Questions Paper 3

iGCSE Biology (0610)-10.1 Diseases and immunity – iGCSE Style Questions Paper 3

Question

(a) Pathogens are disease-causing organisms. Describe how gastric juice in the stomach helps to defend the body against pathogens in food.
(b) Norovirus is a pathogen that affects the stomach and intestines, causing vomiting and diarrhoea. Fig. 3.1 shows how norovirus is transmitted from person to person.
(i) Using the information in Fig. 3.1, calculate the percentage of people that catch norovirus by direct contact with an infected person.
(ii) In one area, $300$ people caught norovirus. Using Fig. 3.1, calculate how many of the $300$ people caught the virus from contaminated water.
(c) Describe ways to prevent the indirect transmission of norovirus.
(d) State one body defence that may prevent a virus in the air from reaching the lungs.
(e) Some bacteria are pathogens. Fig. 3.2 is a diagram of a bacterium.
Identify the structures labelled A, B and C in Fig. 3.2.
▶️ Answer/Explanation
Detailed Solution & Analysis

(a) Defence via Gastric Juice
Gastric juice contains hydrochloric acid ($\text{HCl}$). This creates an acidic environment (low pH) which kills pathogens (such as bacteria) that are ingested with food. This acts as a chemical barrier preventing infection.

(b) Data Analysis from Fig. 3.1
(i) To find the percentage for direct contact, subtract the other modes of transmission from $100\%$:
$$100\% – (54\% + 11\% + 9\%) = 100\% – 74\% = \mathbf{26\%}$$
(ii) The chart states that $11\%$ of cases are from contaminated water. To calculate the number of people out of 300:
$$\frac{11}{100} \times 300 = 0.11 \times 300 = \mathbf{33} \text{ people}$$

(c) Preventing Indirect Transmission
Indirect transmission occurs via contaminated surfaces, food, or water. Preventive measures include:

  • Hygienic food preparation: Ensuring food is cooked thoroughly and stored correctly.
  • Clean water supply: Boiling or treating water (chlorination) to kill pathogens.
  • Personal hygiene: Washing hands thoroughly after using the toilet and before handling food.
  • Waste disposal: Proper treatment of sewage to prevent water source contamination.

(d) Respiratory Defences
Body defences that prevent viruses in the air from reaching the lungs include:

  • Mucus: Produced by goblet cells in the trachea and bronchi; it traps airborne particles and pathogens.
  • Cilia: Hair-like structures on the lining of the airways that beat to sweep mucus (containing trapped pathogens) away from the lungs towards the throat to be swallowed.
  • Nose hairs: Trap larger dust particles and pathogens entering the nose.

(e) Bacterium Structure
Based on the standard structure of a bacterial cell:

  • A: Cell Wall (Provides structural support and protection).
  • B: Cytoplasm (Site of metabolic reactions).
  • C: Plasmid (Small circular loop of DNA).
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