(a) Describe the role of progesterone in pregnancy.
(b) Fig. 5.1 shows a drawing of a section of a human placenta. The arrows show the direction of blood flow.
Substances move across the placenta by diffusion.
(i) State the names of two useful substances that move from the blood of the mother to the blood of the fetus.
(ii) Using the information in Fig. 5.1, suggest how the placenta is adapted for efficient diffusion.
(c) The Rhesus (Rh) factor is a protein that is found on the surface of red blood cells in some people. If the protein is present then the individual is Rh positive.
The allele for the presence of the Rh factor is dominant and is represented by the letter D. The recessive allele is represented by the letter d.
If a mother is Rh negative and the fetus is Rh positive there can be problems during pregnancy.
A Rh negative mother and a heterozygous Rh positive father have a child.
Complete the Punnett square and determine the probability of the child being Rh positive.
▶️ Answer/Explanation
(a)
Progesterone plays several crucial roles in maintaining pregnancy:
- It maintains the thickness of the uterine lining (endometrium) to support the developing embryo
- It prevents the menstrual cycle from continuing during pregnancy by inhibiting the secretion of FSH and LH
- It inhibits contractions of the uterine muscles, preventing premature labor
- It prevents the development of additional follicles and ovulation during pregnancy
Without sufficient progesterone, the uterine lining would break down, leading to a miscarriage.
(b)(i)
Two useful substances that move from mother to fetus:
- Oxygen – essential for fetal respiration and energy production
- Glucose – provides energy for fetal growth and development
Other acceptable answers include amino acids, water, ions, and antibodies.
(b)(ii)
The placenta is adapted for efficient diffusion through:
- Large surface area: The numerous villi and microvilli increase the area available for exchange
- Short diffusion distance: The placental membrane is very thin, allowing rapid diffusion
- Maintained concentration gradient: The constant flow of maternal and fetal blood ensures substances continue to diffuse
- Good blood supply: Both maternal and fetal sides have extensive capillary networks
(c)
Punnett square:
Probability of child being Rh positive (having at least one D allele): 50% or 0.5 or ½
Explanation: The mother can only pass on ‘d’ alleles (as she’s Rh negative), while the father can pass either ‘D’ or ‘d’ (as he’s heterozygous). This results in two possible Rh positive (Dd) and two Rh negative (dd) combinations out of four, giving a 50% chance.
Question
Fig. 4.1 is a diagram of the human female reproductive system.
(a) Complete Table 4.1 to show the letter and the name of each of the structures that perform
these functions.
(b) Fertilization is the fusion of the nuclei of a male gamete and a female gamete resulting in a
zygote.
State the number of chromosomes present in a human:
female gamete
zygote
(c) Chlamydia is a sexually transmitted infection (STI).
Fig. 4.2 shows the number of reported cases of chlamydia in females in each age group in
one country
Describe the results shown by the data in Fig. 4.2.
(d) Chlamydia is caused by a bacterium.
(i) Suggest a treatment for chlamydia. [1]
(ii) State the name of one other STI [1]
(iii) Complete the sentences about the spread of STIs.
STIs are transmitted through the transfer of ……………………………………….. during sexual
contact. One way individuals can avoid the spread of STIs is to use a type of
……………………………………….. contraception. One example of this type of contraception
is ……………………………………….. . [3]
[Total: 14]
Answer/Explanation
Ans
4 (a)
4 (b) 23 ;
46 / 23 pairs ;
4 (c) 1 cases increases then decrease ;
2 large increase between 10–14 and 15–19 ;
3 most cases in the 15–19 age group ;
4 from 15–19 number of cases decrease / from 20–24 number of cases steep
decrease ;
5 no cases above 55 years old / in 55–64 age group / 65+ age group ;
6 data quote with number of cases and age group ;
4 (d) (i) antibiotics ;
4 (d) (ii) HIV ;
4 (d) (iii) (named) bodily fluids / sexual fluid ;
barrier ;
condom / femidom ;